A brain–computer interface (BCI), sometimes called a direct neural interface or a brain–machine interface (BMI), is a direct communication pathway between the brain and an external device. BCIs are often aimed at assisting, augmenting or repairing human cognitive or sensory-motor functions.
Research on BCIs began in the 1970s at the University of California Los Angeles (UCLA) under a grant from the National Science Foundation, followed by a contract from DARPA. The papers published after this research also mark the first appearance of the expression brain–computer interface in scientific literature.
The field of BCI research and development has since focused primarily on neuroprosthetics applications that aim at restoring damaged hearing, sight and movement. remarkable
The History of Brain-Computer-Interfaces (BCI) starts with Hans Berger's discovery of the electrical activity of human brain and the development of Electroencephalography (EEG). In 1924 Berger was the first one who recorded an EEG from a human brain. By analyzing EEGs Berger was able to identify different waves or rhythms which are present in a brain, as the Alpha Wave (8-12 Hz), also known as Berger's Wave.
Berger's first recording device was very rudimentary. He inserted silver wires under the scalp of his patients. Those were replaced by silver foils which were attached to the patients head by rubber bandages later on.
Berger connected these sensors to a Lippmann Capillary Electrometer, with disappointing results. More sophisticated measuring devices such as the Siemens double-coil recording galvanometer, which displayed electric voltages as small as one ten thousandth of a volt, led to success.
Berger analyzed the interrelation of alternations in his EEG wave diagrams with brain diseases. EEGs permitted completely new possibilities for the research of Human brain activities.
2.BCI versus neuroprosthetics
Neuroprosthetics is an area of neuroscience concerned with neural prostheses—using artificial devices to replace the function of impaired nervous systems and brain related problems or sensory organs. The most widely used neuroprosthetic device is the cochlear implant, which, as of 2006, has been implanted in approximately 100,000 people worldwide. There are also several neuroprosthetic devices that aim to restore vision, including retinal implants.
The differences between BCIs and neuroprosthetics are mostly in the ways the terms are used: neuroprosthetics typically connect the nervous system to a device, whereas BCIs usually connect the brain (or nervous system) with a computer system. Practical neuroprosthetics can be linked to any part of the nervous system—for example, peripheral nerves—while the term "BCI" usually designates a narrower class of systems which interface with the central nervous system.
The terms are sometimes used interchangeably. Neuroprosthetics and BCIs seek to achieve the same aims, such as restoring sight, hearing, movement, ability to communicate, and even cognitive function. Both use similar experimental methods and surgical techniques.
3.Animal BCI research
Rats implanted with BCIs in Theodore Berger's experiments
Several laboratories have managed to record signals from monkey and rat cerebral cortices in order to operate BCIs to carry out movement. Monkeys have navigated computer cursors on screen and commanded robotic arms to perform simple tasks simply by thinking about the task and without any motor output. In May 2008 photographs that showed a monkey operating a robotic arm with its mind at the
were published in
a number of well known science journals and magazines.
Other research on cats has decoded visual signals. Pittsburgh
3.1.Prominent research successes
Phillip Kennedy and colleagues built the first intracortical brain–computer interface by implanting neurotrophic-cone electrodes into monkeys.
Yang Dan and colleagues' recordings of cat vision using a BCI implanted in the lateral geniculate nucleus (top row: original image; bottom row: recording)
In 1999, researchers led by Yang Dan at University of California, Berkeley decoded neuronal firings to reproduce images seen by cats. The team used an array of electrodes embedded in the thalamus (which integrates all of the brain’s sensory input) of sharp-eyed cats. Researchers targeted 177 brain cells in the thalamus lateral geniculate nucleus area, which decodes signals from the retina. The cats were shown eight short movies, and their neuron firings were recorded. Using mathematical filters, the researchers decoded the signals to generate movies of what the cats saw and were able to reconstruct recognizable scenes and moving objects. Similar results in humans have since been achieved by researchers in
(see below). Japan
Miguel Nicolelis has been a prominent proponent of using multiple electrodes spread over a greater area of the brain to obtain neuronal signals to drive a BCI. Such neural ensembles are said to reduce the variability in output produced by single electrodes, which could make it difficult to operate a BCI.
After conducting initial studies in rats during the 1990s, Nicolelis and his colleagues developed BCIs that decoded brain activity in owl monkeys and used the devices to reproduce monkey movements in robotic arms. Monkeys have advanced reaching and grasping abilities and good hand manipulation skills, making them ideal test subjects for this kind of work.
By 2000, the group succeeded in building a BCI that reproduced owl monkey movements while the monkey operated a joystick or reached for food. The BCI operated in real time and could also control a separate robot remotely over Internet protocol. But the monkeys could not see the arm moving and did not receive any feedback, a so-called open-loop BCI.
Diagram of the BCI developed by Miguel Nicolelis and colleagues for use on Rhesus monkeys
Later experiments by Nicolelis using rhesus monkeys succeeded in closing the feedback loop and reproduced monkey reaching and grasping movements in a robot arm. With their deeply cleft and furrowed brains, rhesus monkeys are considered to be better models for human neurophysiology than owl monkeys. The monkeys were trained to reach and grasp objects on a computer screen by manipulating a joystick while corresponding movements by a robot arm were hidden. The monkeys were later shown the robot directly and learned to control it by viewing its movements. The BCI used velocity predictions to control reaching movements and simultaneously predicted hand gripping force.
Other labs that develop BCIs and algorithms that decode neuron signals include John Donoghue from Brown University, Andrew Schwartz from the University of Pittsburgh and Richard Andersen from Caltech. These researchers were able to produce working BCIs even though they recorded signals from far fewer neurons than Nicolelis (15–30 neurons versus 50–200 neurons).
Donoghue's group reported training rhesus monkeys to use a BCI to track visual targets on a computer screen with or without assistance of a joystick (closed-loop BCI). Schwartz's group created a BCI for three-dimensional tracking in virtual reality and also reproduced BCI control in a robotic arm. The group created headlines when they demonstrated that a monkey could feed itself pieces of zucchini using a robotic arm controlled by the animal's own brain signals.
Andersen's group used recordings of premovement activity from the posterior parietal cortex in their BCI, including signals created when experimental animals anticipated receiving a reward.
In addition to predicting kinematic and kinetic parameters of limb movements, BCIs that predict electromyographic or electrical activity of muscles are being developed. Such BCIs could be used to restore mobility in paralyzed limbs by electrically stimulating muscles.
Miguel Nicolelis et al. showed that activity of large neural ensembles can predict arm position. This work made possible creation of brain–machine interfaces — electronic devices that read arm movement intentions and translate them into movements of artificial actuators. Carmena et al. programmed the neural coding in a brain–machine interface allowed a monkey to control reaching and grasping movements by a robotic arm, and Lebedev et al. argued that brain networks reorganize to create a new representation of the robotic appendage in addition to the representation of the animal's own limbs.
The biggest impediment of BCI technology at present is the lack of a sensor modality that provides safe, accurate, and robust access to brain signals. It is conceivable or even likely that such a sensor will be developed within the next twenty years. The use of such a sensor should greatly expand the range of communication functions that can be provided using a BCI.
Development and implementation of a Brain–Computer Interface (BCI) system is complex and time consuming. In response to this problem, Dr. Gerwin Schalk has been developing a general-purpose system for BCI research, called BCI2000. BCI2000 has been in development since 2000 in a project led by the Brain–Computer Interface R&D Program at the
Center of the New York State
Department of Health in . Albany,
New York, USA
A new 'wireless' approach uses light-gated ion channels such as Channelrhodopsin to control the activity of genetically defined subsets of neurons in vivo. In the context of a simple learning task, illumination of transfected cells in the somatosensory cortex influenced the decision making process of freely moving mice.
The Annual BCI Award, endowed with 3,000 USD, is an accolade to recognize outstanding and innovative research done in the field of Brain-Computer Interfaces. Each year, a renowned research laboratory is asked to judge the submitted projects and to award the prize. The jury consists of world-leading BCI experts recruited by the awarding laboratory. Cuntai Guan, Kai Keng Ang, Karen Sui Geok Chua, Beng Ti Ang from A*STAR in
with the project "Motor imagery-based Brain-Computer Interface robotic
rehabilitation for stroke" won the BCI Award 2010. Singapore
4.Human BCI research
Invasive BCI research has targeted repairing damaged sight and providing new functionality to persons with paralysis. Invasive BCIs are implanted directly into the grey matter of the brain during neurosurgery. As they rest in the grey matter, invasive devices produce the highest quality signals of BCI devices but are prone to scar-tissue build-up, causing the signal to become weaker or even lost as the body reacts to a foreign object in the brain.
Jens Naumann, a man with acquired blindness, being interviewed about his vision BCI on CBS's The Early Show
In vision science, direct brain implants have been used to treat non-congenital (acquired) blindness. One of the first scientists to come up with a working brain interface to restore sight was private researcher William Dobelle.
Dobelle's first prototype was implanted into "Jerry", a man blinded in adulthood, in 1978. A single-array BCI containing 68 electrodes was implanted onto Jerry’s visual cortex and succeeded in producing phosphenes, the sensation of seeing light. The system included cameras mounted on glasses to send signals to the implant. Initially, the implant allowed Jerry to see shades of grey in a limited field of vision at a low frame-rate. This also required him to be hooked up to a two-ton mainframe, but shrinking electronics and faster computers made his artificial eye more portable and now enable him to perform simple tasks unassisted.
Dummy unit illustrating the design of a BrainGate interface
In 2002, Jens Naumann, also blinded in adulthood, became the first in a series of 16 paying patients to receive Dobelle’s second generation implant, marking one of the earliest commercial uses of BCIs. The second generation device used a more sophisticated implant enabling better mapping of phosphenes into coherent vision. Phosphenes are spread out across the visual field in what researchers call the starry-night effect. Immediately after his implant, Jens was able to use his imperfectly restored vision to drive slowly around the parking area of the research institute.
BCIs focusing on motor neuroprosthetics aim to either restore movement in individuals with paralysis or provide devices to assist them, such as interfaces with computers or robot arms.
University in led by Philip Kennedy and Roy Bakay
were first to install a brain implant in a human that produced signals of high
enough quality to simulate movement. Their patient, Johnny Ray (1944–2002),
suffered from ‘locked-in syndrome’
after suffering a brain-stem stroke in 1997. Ray’s implant
was installed in 1998 and he lived long enough to start working with the
implant, eventually learning to control a computer cursor; he died in 2002 of a
brain aneurysm. Atlanta
Tetraplegic Matt Nagle became the first person to control an artificial hand using a BCI in 2005 as part of the first nine-month human trial of Cyberkinetics Neurotechnology’s BrainGate chip-implant. Implanted in Nagle’s right precentral gyrus (area of the motor cortex for arm movement), the 96-electrode BrainGate implant allowed Nagle to control a robotic arm by thinking about moving his hand as well as a computer cursor, lights and TV. One year later, professor Jonathan Wolpaw received the prize of the Altran Foundation for Innovation to develop a Brain Computer Interface with electrodes located on the surface of the skull, instead of directly in the brain.
Partially invasive BCI devices are implanted inside the skull but rest outside the brain rather than within the grey matter. They produce better resolution signals than non-invasive BCIs where the bone tissue of the cranium deflects and deforms signals and have a lower risk of forming scar-tissue in the brain than fully-invasive BCIs.
Electrocorticography (ECoG) measures the electrical activity of the brain taken from beneath the skull in a similar way to non-invasive electroencephalography (see below), but the electrodes are embedded in a thin plastic pad that is placed above the cortex, beneath the dura mater. ECoG technologies were first trialed in humans in 2004 by Eric Leuthardt and Daniel Moran from
Washington University in . In a later trial, the researchers enabled a
teenage boy to play Space Invaders
using his ECoG implant.
This research indicates that control is rapid, requires minimal training, and
may be an ideal tradeoff with regards to signal fidelity and level of
(Note: These electrodes were not implanted in the patients for BCI experiments. The patient was suffering from severe epilepsy and had the electrodes temporarily implanted to help his physicians localize seizure foci; the researchers simply took advantage of this.)
Light Reactive Imaging BCI devices are still in the realm of theory. These would involve implanting a laser inside the skull. The laser would be trained on a single neuron and the neuron's reflectance measured by a separate sensor. When the neuron fires, the laser light pattern and wavelengths it reflects would change slightly. This would allow researchers to monitor single neurons but require less contact with tissue and reduce the risk of scar-tissue build-up.
This signal can be either subdural or epidural, but is not taken from within the brain parenchyma itself. It has not been studied extensively until recently due to the limited access of subjects. Currently, the only manner to acquire the signal for study is through the use of patients requiring invasive monitoring for localization and resection of an epileptogenic focus.
ECoG is a very promising intermediate BCI modality because it has higher spatial resolution, better signal-to-noise ratio, wider frequency range, and lesser training requirements than scalp-recorded EEG, and at the same time has lower technical difficulty, lower clinical risk, and probably superior long-term stability than intracortical single-neuron recording. This feature profile and recent evidence of the high level of control with minimal training requirements shows potential for real world application for people with motor disabilities.
As well as invasive experiments, there have also been experiments in humans using non-invasive neuroimaging technologies as interfaces. Signals recorded in this way have been used to power muscle implants and restore partial movement in an experimental volunteer. Although they are easy to wear, non-invasive implants produce poor signal resolution because the skull dampens signals, dispersing and blurring the electromagnetic waves created by the neurons. Although the waves can still be detected it is more difficult to determine the area of the brain that created them or the actions of individual neurons.
Recordings of brainwaves produced by an electroencephalogram
Electroencephalography (EEG) is the most studied potential non-invasive interface, mainly due to its fine temporal resolution, ease of use, portability and low set-up cost. But as well as the technology's susceptibility to noise, another substantial barrier to using EEG as a brain–computer interface is the extensive training required before users can work the technology. For example, in experiments beginning in the mid-1990s, Niels Birbaumer of the
of Tübingen in trained
severely paralysed people to self-regulate the slow cortical potentials
in their EEG to such an extent that these signals could be used as a binary
signal to control a computer cursor.
(Birbaumer had earlier trained epileptics to prevent
impending fits by controlling this low voltage wave.) The experiment saw ten
patients trained to move a computer cursor by controlling their brainwaves. The
process was slow, requiring more than an hour for patients to write 100
characters with the cursor, while training often took many months. Germany
Another research parameter is the type of waves measured. Birbaumer's later research with Jonathan Wolpaw at
has focused on developing technology that would allow users to choose the brain
signals they found easiest to operate a BCI, including mu and beta rhythms. New York State University
A further parameter is the method of feedback used and this is shown in studies of P300 signals. Patterns of P300 waves are generated involuntarily (stimulus-feedback) when people see something they recognize and may allow BCIs to decode categories of thoughts without training patients first. By contrast, the biofeedback methods described above require learning to control brainwaves so the resulting brain activity can be detected.
Lawrence Farwell and Emanuel Donchin developed an EEG-based brain–computer interface in the 1980s. Their "mental prosthesis" used the P300 brainwave response to allow subjects, including one paralyzed Locked-In syndrome patient, to communicate words, letters, and simple commands to a computer and thereby to speak through a speech synthesizer driven by the computer. A number of similar devices have been developed since then. In 2000, for example, research by Jessica Bayliss at the University of Rochester showed that volunteers wearing virtual reality helmets could control elements in a virtual world using their P300 EEG readings, including turning lights on and off and bringing a mock-up car to a stop.
In the early 90s Babak Taheri, at UC DAVIS demonstrated the first single and also multichannel dry active electrode arrays using micro-machining. The single channel dry EEG electrode construction and results were published in 1994. The arrayed electrode was also demonstrated to perform well compared to Ag/AgCl electrodes. The device consisted of four sites of sensors with integrated electronics to reduce noise by impedance matching. The advantages of such electrodes are: (1) no electrolyte used, (2) no skin preparation, (3) significantly reduced sensor size, and (4) compatibility with EEG monitoring systems. The active electrode array is an integrated system made of an array of capacitive sensors with local integrated circuitry housed in a package with batteries to power the circuitry. This level of integration was required to achieve the functional performance obtained by the electrode. The electrode was tested on an electrical test bench and on human subjects in four modalities of EEG activity, namely: (1) spontaneous EEG, (2) sensory event-related potentials, (3) brain stem potentials, and (4) cognitive event-related potentials. The performance of the dry electrode compared favorably with that of the standard wet Ag/AgCl electrodes in terms of skin preparation, no gel requirements (dry), and higher signal-to-noise ratio. In 1999, researchers at Case Western Reserve University led by Hunter Peckham, used 64-electrode EEG skullcap to return limited hand movements to quadriplegic Jim Jatich. As Jatich concentrated on simple but opposite concepts like up and down, his beta-rhythm EEG output was analysed using software to identify patterns in the noise. A basic pattern was identified and used to control a switch: Above average activity was set to on, below average off. As well as enabling Jatich to control a computer cursor the signals were also used to drive the nerve controllers embedded in his hands, restoring some movement.
Electronic neural networks have been deployed which shift the learning phase from the user to the computer. Experiments by scientists at the Fraunhofer Society in 2004 using neural networks led to noticeable improvements within 30 minutes of training.
Experiments by Eduardo Miranda aim to use EEG recordings of mental activity associated with music to allow the disabled to express themselves musically through an encephalophone.
Ramaswamy Palaniappan has pioneered the development of BCI for use as biometrics to identify/authenticate a person. The BCI group at University of Essex has also developed analogue cursor control using thoughts.
The Emotiv company has been selling a commercial video game controller, known as the Epoc, since December 2009. The Epoc uses electromagnetic sensors.
The first BCI session with 100% accuracy (based on 80 right hand and 80 left hand movement imaginations) was recorded in 1998 by Christoph Guger. The BCI system used 27 electrodes overlaying the sensorimotor cortex, weighted the electrodes with Common Spatial Patterns, calculated the running variance and used a linear discriminant analysis.
Research is ongoing into military use of BCIs. Since the 1970s DARPA is funding research on this topic. The current idea is user-to-user communication through analysis of neural signals.The project "Silent Talk" aims to detect and analyze the word-specific neural signals, using EEG, which occur before speech is vocalized, and to see if the patterns are generalizable.
MEG and MRI
ATR Labs' reconstruction of human vision using fMRI (top row: original image; bottom row: reconstruction from mean of combined readings)
Magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) have both been used successfully as non-invasive BCIs. In a widely reported experiment, fMRI allowed two users being scanned to play Pong in real-time by altering their haemodynamic response or brain blood flow through biofeedback techniques.
fMRI measurements of haemodynamic responses in real time have also been used to control robot arms with a seven second delay between thought and movement.
More recently, research developed in the Advanced Telecommunications Research (ATR) Computational Neuroscience Laboratories in Kyoto,
Japan allowed the scientists
to reconstruct images directly from the brain and display them on a computer.
The article announcing these achievements was the cover story of the journal Neuron of 10 December 2008,
While the early results are limited to black and white images of 10x10 squares
(pixels), according to the researchers further
development of the technology may make it possible to achieve color images, and
even view or record dreams.
Commercialization and companies
John Donoghue and fellow researchers founded Cyberkinetics. The company markets its electrode arrays under the BrainGate product name and has set the development of practical BCIs for humans as its major goal. The BrainGate is based on the Utah Array developed by Dick Normann.
Philip Kennedy founded Neural Signals in 1987 to develop BCIs that would allow paralysed patients to communicate with the outside world and control external devices. As well as an invasive BCI, the company also sells an implant to restore speech. Neural Signals' Brain Communicator BCI device uses glass cones containing microelectrodes coated with proteins to encourage the electrodes to bind to neurons.
Although 16 paying patients were treated using William Dobelle's vision BCI, new implants ceased within a year of Dobelle's death in 2004. A company controlled by Dobelle, Avery Biomedical Devices, and Stony Brook University are continuing development of the implant, which has not yet received Food and Drug Administration approval in the United States for human implantation.
Ambient, at a TI developers conference in early 2008, demoed a product they have in development call The Audeo. The Audeo is being developed to create a human–computer interface for communication without the need of physical motor control or speech production. Using signal processing, unpronounced speech representing the thought of the mind can be translated from intercepted neurological signals.
Mindball is a product developed and commercialized by Interactive Productline in which players compete to control a ball's movement across a table by becoming more relaxed and focused Interactive Productline is a Swedish company whose objective is to develop and sell easy understandable EEG products that train the ability to relax and focus.
An Austrian company, Guger Technologies, g.tec, has been offering Brain Computer Interface systems since 1999. The company provides base BCI models as development platforms for the research community to build upon, including the P300 Speller, Motor Imagery, and mu-rhythm. They commercialized a Steady State Visual Evoked Potiential BCI solution in 2008 with 4 degrees of machine control.
A Spanish company, Starlab, has entered this market in 2009 with a wireless 4-channel system called Enobio. Designed for research purposes the system provides a platform for application development.
There are three main consumer-devices commercial-competitors in this area (launch date mentioned in brackets) which have launched such devices primarily for gaming- and PC-users:
· Neural Impulse Actuator (April, 2008)
· Emotiv Systems (December, 2009)
· NeuroSky (MindSet – June, 2009; Uncle Milton Force Trainer – Fall 2009, Mattel MindFlex – Summer, 2009)
2010 the world's first personal EEG-based spelling system came to the market: intendiX. It works with 8 active EEG electrodes and uses the P300 principle to type on a keyboard like matrix. Besides writing a text the patient can also use the system to trigger an alarm, let the computer speak the written text, print out or copy the text into an e-mail or to send commands to external devices. Recently g.tec developed active dry electrodes that work for P300, SSVEP and motor imagery based BCI systems: g.SAHARA.
Main article: Cultured neuronal network
Researchers have built devices to interface with neural cells and entire neural networks in cultures outside animals. As well as furthering research on animal implantable devices, experiments on cultured neural tissue have focused on building problem-solving networks, constructing basic computers and manipulating robotic devices. Research into techniques for stimulating and recording from individual neurons grown on semiconductor chips is sometimes referred to as neuroelectronics or neurochips.
World first: Neurochip developed by Caltech researchers Jerome Pine and Michael Maher
Development of the first working neurochip was claimed by a Caltech team led by Jerome Pine and Michael Maher in 1997. The Caltech chip had room for 16 neurons.
In 2003, a team led by Theodore Berger at the
started work on a
neurochip designed to function as an artificial or prosthetic hippocampus. The neurochip was designed to
function in rat brains and is intended as a prototype for the eventual
development of higher-brain prosthesis. The hippocampus was chosen because it
is thought to be the most ordered and structured part of the brain and is the
most studied area. Its function is to encode experiences for storage as
long-term memories elsewhere in the brain. University of Southern California
Thomas DeMarse at the
used a culture of 25,000 neurons taken from a rat's brain to fly a F-22 fighter
jet aircraft simulator.
After collection, the cortical neurons were cultured in a petri dish and rapidly began to reconnect
themselves to form a living neural network. The cells were arranged over a grid
of 60 electrodes and used to control the pitch and yaw functions of the
simulator. The study's focus was on understanding how the human brain performs
and learns computational tasks at a cellular level. University of Florida
There has not been a vigorous debate about the ethical implications of BCIs, even though there are several commercially available systems such as brain pacemakers used to treat neurological conditions, and could theoretically be used to modify other behaviours.
Important topics in the neuroethical debate are:
· obtaining informed consent from people who have difficulty communicating,
· risk/benefit analysis,
· shared responsibility of BCI teams (e.g. how to ensure that responsible group decisions can be made),
· the consequences of BCI technology for the quality of life of patients and their families,
· side-effects (e.g. neurofeedback of sensorimotor rhythm training is reported to affect sleep quality),
· personal responsibility and its possible constraints (e.g. who is responsible for erroneous actions with a neuroprosthesis),
· issues concerning personality and personhood and its possible alteration,
· therapeutic applications and their possible exceedance,
· questions of research ethics that arise when progressing from animal experimentation to application in human subjects,
· mind-reading and privacy,
· selective enhancement and social stratification, and
· communication to the media.